解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)-CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O-GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic subunits (PKAcs) were po...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12449
更新日期:2016-06-01 00:00:00
abstract::Lactic-acid bacteria are widely recognized beneficial host associated groups of the microbiota of humans and animals. Some lactic-acid bacteria have the ability to extend the lifespan of the model animals. The mechanisms behind the probiotic effects of bacteria are not entirely understood. Recently, we reported the be...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12431
更新日期:2016-04-01 00:00:00
abstract::Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has r...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/acel.12424
更新日期:2016-02-01 00:00:00
abstract::Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major contributor to disability and frailty in the elderly. Previous studies found a protective effect of reduced histone deacetylase activity in models of neurogenic muscle atrophy. Because loss of muscle mass during aging is associated with...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12387
更新日期:2015-12-01 00:00:00
abstract::Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age-related declines in physical function. Early evidence suggests that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve mitochondrial function. Here, we show that 10 weeks of dietary eicosapentaenoic acid (EPA) su...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12352
更新日期:2015-10-01 00:00:00
abstract::The age-associated decline of immune responses causes high susceptibility to infections and reduced vaccine efficacy in the elderly. However, the mechanisms underlying age-related deficits are unclear. Here, we found that the expression and signaling of flagellin (FlaB)-dependent Toll-like receptor 5 (TLR5), unlike th...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12383
更新日期:2015-10-01 00:00:00
abstract::Aberrant neural progenitor cell (NPC) proliferation and self-renewal have been linked to age-related neurodegeneration and neurodegenerative disorders including Alzheimer's disease (AD). Rhizoma Acori tatarinowii is a traditional Chinese herbal medicine against cognitive decline. In this study, we found that the extra...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12356
更新日期:2015-10-01 00:00:00
abstract::Adequate energy stores are essential for survival, and sophisticated neuroendocrine mechanisms evolved to stimulate foraging in response to nutrient deprivation. Food search behavior is usually investigated in young animals, and it is not known how aging alters this behavior. To address this question in Drosophila mel...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12361
更新日期:2015-10-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is regarded as one of the serious risk factors for age-related cognitive impairment; however, a causal link between these two diseases has so far not been established. It was recently discovered that, apart from high D-glucose levels, T2DM patients also display abnormally high concentra...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12355
更新日期:2015-10-01 00:00:00
abstract::The aim of this study was to determine the mechanism underlying the association between one-carbon metabolism and DNA methylation during chronic degenerative joint disorder, osteoarthritis (OA). Articular chondrocytes were isolated from human OA cartilage and normal cartilage biopsied, and the degree of cartilage degr...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12363
更新日期:2015-10-01 00:00:00
abstract::Downregulation of insulin-like growth factor (IGF) pathways prolongs lifespan in various species, including mammals. Still, the cellular mechanisms by which IGF signaling controls the aging trajectory of individual organs are largely unknown. Here, we asked whether suppression of IGF-I receptor (IGF-1R) in adult stem ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12365
更新日期:2015-10-01 00:00:00
abstract::Aging is commonly associated with a structural deterioration of skin that compromises its barrier function, healing, and susceptibility to disease. Several lines of evidence show that these changes are driven largely by impaired tissue mitochondrial metabolism. While exercise is associated with numerous health benefit...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12341
更新日期:2015-08-01 00:00:00
abstract::Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12305
更新日期:2015-08-01 00:00:00
abstract::The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of d...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12344
更新日期:2015-08-01 00:00:00
abstract::Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a larger effect in females than males. Traditionally, this has been attributed to a stronger trade-off between LS and reproduction in females than in males that is mediated by the intake of calories. Recent studies, however, ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12333
更新日期:2015-08-01 00:00:00
abstract::Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult mice. Lgr5(+) cells are generated at late stages of retinal development and exh...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12346
更新日期:2015-08-01 00:00:00
abstract::Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity remains incompletely understo...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12320
更新日期:2015-06-01 00:00:00
abstract::Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of cal...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12259
更新日期:2015-06-01 00:00:00
abstract::Advanced glycation end products (AGEs) are formed when glucose reacts nonenzymatically with proteins; these modifications are implicated in aging and pathogenesis of many age-related diseases including type II diabetes, atherosclerosis, and neurodegenerative disorders. Thus, pharmaceutical interventions that can reduc...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12327
更新日期:2015-06-01 00:00:00
abstract::Disruption of telomere maintenance pathways leads to accelerated entry into cellular senescence, a stable proliferative arrest that promotes aging-associated disorders in some mammals. The budding yeast CST complex, comprising Cdc13, Stn1, and Ctc1, is critical for telomere replication, length regulation, and end prot...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12289
更新日期:2015-06-01 00:00:00
abstract::Recent studies demonstrate that aging exacerbates hypertension-induced cognitive decline, but the specific age-related mechanisms remain elusive. Cerebral microhemorrhages (CMHs) are associated with rupture of small intracerebral vessels and are thought to progressively impair neuronal function. To determine whether a...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12315
更新日期:2015-06-01 00:00:00
abstract::Aging is influenced by endocrine pathways including the growth hormone/insulin-like growth factor-1 (GH/IGF) axis. Mitochondrial function has also been linked to the aging process, but the relevant mitochondrial signals mediating the effects of mitochondria are poorly understood. Humanin is a novel signaling peptide t...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12243
更新日期:2014-10-01 00:00:00
abstract::Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generations of telomerase-def...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12237
更新日期:2014-10-01 00:00:00
abstract::Although dietary restriction (DR) is known to extend lifespan across species, from yeast to mammals, the signalling events downstream of food/nutrient perception are not well understood. In Caenorhabditis elegans, DR is typically attained either by using the eat-2 mutants that have reduced pharyngeal pumping leading t...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12218
更新日期:2014-08-01 00:00:00
abstract::Accumulating evidence suggests a role for microRNAs (miRNAs) in regulating various processes of mammalian postnatal development and aging. To investigate the changes in blood-based miRNA expression from preterm infants to adulthood, we compared 365 miRNA expression profiles in a screening set of preterm infants and ad...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12225
更新日期:2014-08-01 00:00:00
abstract::Cardiac performance decreases with age, which is a major risk factor for cardiovascular disease and mortality in the aging human population, but the molecular mechanisms underlying cardiac aging are still poorly understood. Investigating the role of integrin-linked kinase (ilk) and β1-integrin (myospheroid, mys) in Dr...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12193
更新日期:2014-06-01 00:00:00
abstract::Age-associated ventriculomegaly is typically attributed to neurodegeneration; however, additional factors might initiate or contribute to progressive ventricular expansion. By directly linking postmortem human MRI sequences with histological features of periventricular tissue, we show that substantial lateral ventricl...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12184
更新日期:2014-04-01 00:00:00
abstract::The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approac...
journal_title:Aging cell
pub_type: 杂志文章,meta分析
doi:10.1111/acel.12160
更新日期:2014-04-01 00:00:00
abstract::Aging is associated with a large number of both phenotypic and molecular changes, but for most of these, it is not known whether these changes are detrimental, neutral, or protective. We have identified a conserved Caenorhabditis elegans GATA transcription factor/MTA-1 homolog egr-1 (lin-40) that extends lifespan and ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12179
更新日期:2014-04-01 00:00:00
abstract::One goal of aging research is to find drugs that delay the onset of age-associated disease. Studies in invertebrates, particularly Caenorhabditis elegans, have uncovered numerous genes involved in aging, many conserved in mammals. However, which of these encode proteins suitable for drug targeting is unknown. To inves...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12163
更新日期:2014-04-01 00:00:00
abstract::Wnt signaling is a major and highly conserved developmental pathway that guides many important events during embryonic and larval development. In adulthood, misregulation of Wnt signaling has been implicated in tumorigenesis and various age-related diseases. These effects occur through highly complicated cell-to-cell ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12141
更新日期:2014-02-01 00:00:00
abstract::Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significant molecular damage. Animals tightly control ROS levels using sophisticated defense mechanisms, yet the transcriptional pathways that induce ROS defense remain incompletely understood. In the nematode Caenorhabditis eleg...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12154
更新日期:2014-02-01 00:00:00
abstract::Age-related increase in L-type Ca(2+) channel (LTCC) expression in hippocampal pyramidal neurons has been hypothesized to underlie the increased Ca(2+) influx and subsequent reduced intrinsic neuronal excitability of these neurons that lead to age-related cognitive deficits. Here, using specific antibodies against Cav...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12157
更新日期:2014-02-01 00:00:00
abstract::Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effect of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. Here, we describe a large-scale effort to define molecular mechanisms that underlie genotype-spe...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12130
更新日期:2013-12-01 00:00:00
abstract::Although the link between altered stem cell properties and tissue aging has been recognized, the molecular and cellular processes of tendon aging have not been elucidated. As tendons contain stem/progenitor cells (TSPC), we investigated whether the molecular and cellular attributes of TSPC alter during tendon aging an...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12124
更新日期:2013-12-01 00:00:00
abstract::The general control nonderepressible 2 (GCN2) kinase is a nutrient-sensing pathway that responds to amino acids deficiency and induces a genetic program to effectively maintain cellular homeostasis. Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation init...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12101
更新日期:2013-10-01 00:00:00
abstract::Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle resulting in significant healthcare costs in the developed world. However, there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. Here, we demonstrate that a single treatment with the mitochondrial-tar...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12102
更新日期:2013-10-01 00:00:00
abstract::Aging impairs arterial function through oxidative stress and diminished nitric oxide (NO) bioavailability. Life-long caloric restriction (CR) reduces oxidative stress, but its impact on arterial aging is incompletely understood. We tested the hypothesis that life-long CR attenuates key features of arterial aging. Bloo...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12103
更新日期:2013-10-01 00:00:00
abstract::Most human tissues express low levels of telomerase and undergo telomere shortening and eventual senescence; the resulting limitation on tissue renewal can lead to a wide range of age-dependent pathophysiologies. Increasing evidence indicates that the decline in cell division capacity in cells that lack telomerase can...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12099
更新日期:2013-08-01 00:00:00
abstract::Here I comment on the recent contribution by Barrientos et al. J. Neurosci. 32, 14641-14648 (2012) addressing treatment possibilities for surgery-induced cognitive dysfunction. It has been over 15 years since the publication of a landmark study that indicated age as a major risk factor for postoperative cognitive dysf...
journal_title:Aging cell
pub_type: 评论,杂志文章
doi:10.1111/acel.12066
更新日期:2013-06-01 00:00:00